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Axon regeneration in response to injury is determined by the interaction between the extracellular environment In this study, we investigated the role of chemical signaling in axon regeneration in Caenorhabditis However, it remains unclear what signals activate the EGL-30 pathway in axon regeneration. Consistent with this, we found that ascr#5 activates the axon regeneration pathway via SRG-36/SRG-37 Thus, ascaroside signaling promotes axon regeneration by activating the GPCR-Gqα pathway.

2022 GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration However, the potential role of GPR3 in axonal regeneration after neuronal injury has not been elucidated Herein, we investigated retinal GPR3 expression and its possible involvement in axonal regeneration after Evaluation of the effect of GPR3 on axonal regeneration using GPR3 knockout mice revealed that GPR3 in RGCs participates in axonal regeneration after optic nerve crush (ONC) under zymosan stimulation.

systems, where it regulates various processes including neuroendocrine release, cognition, and nerve regeneration

Significantly, we show that GRKs generate distinct phosphorylation barcodes in intracellular loop 2 ( regulate recruitment of the scaffolding protein β-arrestin 2 (βarr2) to APH1A and γ-secretase-mediated Aβ generation the molecular and structural determinants of the APH1A-βarr2 interaction that critically regulate Aβ generation

GPCRs in Neuroscience Heterotrimeric G proteins regulate planarian regeneration and behavior.

September 2022 "Chemerin is the product of the RARRES2 gene which is secreted as a precursor of 143 amino acids. That precursor is inactive, but proteases from the coagulation and fibrinolytic cascades, as well as from inflammatory reactions, process the C-terminus of chemerin to first activate it and then subsequently inactivate it. Chemerin can signal via two G protein-coupled receptors, chem1 and chem2, as well as be bound to a third non-signaling receptor, CCRL2. Chemerin is produced by the liver and secreted into the circulation as a precursor, but it is also expressed in some tissues where it can be activated locally. This review discusses the specific tissue expression of the components of the chemerin system, and the role of different proteases in regulating the activation and inactivation of chemerin. Methods of identifying and determining the levels of different chemerin forms in both mass and activity assays are reviewed. The levels of chemerin in circulation are correlated with certain disease conditions, such as patients with obesity or diabetes, leading to the possibility of using chemerin as a biomarker." Read more at the source #DrGPCR #GPCR #IndustryNews

December 2021 "30/11/2021 Confo will work together with Regeneron to apply its GPCR drug discovery platform spin-off Confo Therapeutics today announced that it has entered into a collaborative agreement with Regeneron

Reviews, GPCRs, and more Heterotrimeric G proteins regulate planarian regeneration and behavior.

the discovery of antibodies, which recognized native receptor Targeting class A GPCRs for hard tissue regeneration phospholipid-binding G protein-coupled receptor Methods & Updates in GPCR Research RediscMol: Benchmarking Molecular Generation translational research project - Institute for Protein Design Generate:Biomedicines Fortifies Leadership in Generative

Subacute SCI is mainly characterized by neuronal apoptosis, axonal demyelination, Wallerian degeneration

pathogenic tau but also show that β-arrestin1 levels are increased in brains of Frontotemporal lobar degeneration

Announces First Patients Dosed in Phase 1b/2 Trial of Restoret™ in Neovascular Age Related Macular Degeneration

Webinars November 25 - 26, 2024 | 6th International Conference on Stem Cell, Tissue Engineering and Regenerat

Development Summit November 25 - 26, 2024 | 6th International Conference on Stem Cell, Tissue Engineering and Regenerat

Pharma and Antiverse Enter Collaboration To Design Novel GPCR- Targeted Antibody Therapeutics Using Generative Europe   NEW November 25 - 26, 2024 | 6th International Conference on Stem Cell, Tissue Engineering and Regenerat