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mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages "The putative medium-chain free fatty acid receptor GPR84 is a G protein-coupled receptor primarily expressed in myeloid cells

insulin signaling mutants reveal regulators of behavior and learning GPCRs in Oncology and Immunology Short-chain fatty acids and cancer The path of GPR87: from a P2Y-like receptor to its role in cancer progression

Reviews, GPCRs, and more Short-chain fatty acids: possible regulators of insulin secretion.

September 2022 "The G-protein-coupled bile acid receptor, Gpbar1 or TGR5, is characterized as a membrane receptor specifically activated by bile acids. effects in different cancer cells upon activating via TGR5 agonists, such as INT-777, ursodeoxycholic acid (UDCA), and taurolithocholic acid (TLCA).

We identified gambogic acid (GA), a natural prenylated xanthone, selectively targeting GPR108.

Lysophosphatidic acids (LPAs) are bioactive phospholipids implicated in a wide range of cellular activities

Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron MN IME was also augmented by the physiological neuromodulator lysophosphatidic acid (LPA) through a mechanism

The medium chain fatty acid receptor GPR84 as well as formyl peptide receptor 2 (FPR2), receptors expressed

Human-associated bacteria encode a variety of bioactive small molecules with growing evidence for N-acyl amides an N-acyltransferase encoded in the obligate human pathogen N. meningitidis and identified 30 N-acyl amides During this process, we also characterized two mammalian N-acyl amides derived from the bovine medium

October 2022 Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat "Introduction: Recurrent hypoglycemia (RH) impairs secretion of counterregulatory hormones. Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory hormones are poorly understood. Objective: To study the effects of RH on metabolic pathways associated with glucose counterregulation within liver, white adipose tissue and skeletal muscle. Methods: Using a widely adopted rodent model of 3-day recurrent hypoglycemia, we first checked expression of counterregulatory hormone G-protein coupled receptors (GPCRs), their inhibitory regulators and downstream enzymes catalyzing glycogen metabolism, gluconeogenesis and lipolysis by qPCR and western blot. Then, we examined epinephrine-induced phosphorylation of PKA substrates to validate adrenergic sensitivity in each organ. Next, we measured hepatic and skeletal glycogen content, degree of breakdown by epinephrine and abundance of phosphorylated glycogen phosphorylase under hypoglycemia and that of phosphorylated glycogen synthase during recovery to evaluate glycogen turnover. Further, we performed pyruvate and lactate tolerance tests to assess gluconeogenesis. Additionally, we measured circulating FFA and glycerol to check lipolysis. The abovementioned studies were repeated in streptozotocin-induced diabetic rat model. Finally, we conducted epinephrine tolerance test to investigate systemic glycemic excursions to counterregulatory hormones. Saline-injected rats served as controls." Read more at the source #DrGPCR #GPCR #IndustryNews

bioinformatics are powerful tools to build modular, reproducible, and reusable pipelines for computer-aided

genes in the D. armandi and carried out bioinformatics predictions on the basis of the deduced amino acid mortality of D. armandi and also led to an increase in trehalose and a decrease in glycogen and free fatty acid.

Insights into GPCR Function Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.

., 2011), although it is widely accepted that medium‐chain fatty acids (MCFAs) can bind to and activate

August 2022 "Aims: The pathophysiological mechanism(s) underlying non-alcoholic fatty liver disease (

Cardiology, Endocrinology, and Taste Pathogenic variants of the GNAS gene introduce an abnormal amino acid Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells. Research CPGL: Prediction of Compound-Protein Interaction by Integrating Graph Attention Network With Long Short-Term Oligomerization of the heteromeric γ-aminobutyric acid receptor GABAB in a eukaryotic cell-free system

Mikel Garcia-Marcos for their work on Get ready to sharpen your tools:A short guide to heterotrimeric phosphorylation-dependent and independent desensitization mechanisms Get ready to sharpen your tools:A short to endosomes GPCRs in Neuroscience An atlas of GPCRs in dopamine neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water intake The tick Ixodes scapularis has five different

You can submit your poster abstracts using this form and short talks will be selected from abstracts. reticulum-mitochondrial coupling in diabetic retinopathy GPCR Binders, Drugs, and more The Leu/Val6.51 Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ9-Tetrahydrocannabinol GPCRs disorders GPCRs in Oncology and Immunology From outside to inside and back again: the lysophosphatidic acid-CCN

Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease The prevalence of non-alcoholic fatty liver disease (NAFLD) is globally increasing.

Molecular mechanism of fatty acid activation of FFAR1.

Molecular mechanism of fatty acid activation of FFAR1. Lysophosphatidic acid, a simple phospholipid with myriad functions.

Nbs typically consist of a single polypeptide chain which contains the antigen-binding site and the effector They are derived from the heavy-chain antibodies found in camelids (such as camels and llamas) and their They can recognize cryptic epitopes often composed of discontinuous amino acid segments and occur only

neurotransmission and chemokine signaling, extending to numerous other GPCR-regulated systems such as free fatty acid receptors (FFARs), now regarded as targets for therapeutic intervention for metabolic diseases

What mariachi song are you most likely to shout along to at 3 AM? AB: Favorite Taco: Taco de suadero (pronounced swa-day-ro), fatty, with meat caramelized in its own fat , tender, and—oh, did I say fatty?

The AlphaFold database encompasses over 200 million proteins, aiding structural biology, protein design They found that AF2 models achieved accurate side-chain predictions and successfully docked high-affinity For the σ2 receptor, AF2 predicted side-chain conformations with an RMSD of 1.1 Å from the crystal structure

proteins (UCPs) are unpaired electron carriers that uncouple oxygen intake by the electron transport chain

neurotransmission and chemokine signaling, extending to numerous other GPCR-regulated systems such as free fatty acid receptors (FFARs), now regarded as targets for therapeutic intervention for metabolic diseases

Submit poster abstracts using this form; short talks will be selected from submissions. weekly Classified GPCR News from August 14 to 20, 2023 Adhesion GPCRs Amelioration of non-alcoholic fatty