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HDAC5 in Depression GPCRs in Oncology and Immunology Structural Basis for the Recognition of GPRC5D by Talquetamab

< GPCR News < GPCRs in Oncology and Immunology Structural Basis for the Recognition of GPRC5D by Talquetamab Talquetamab, a Food and Drug Administration-approved T-cell-directing bispecific antibody developed for Here, we elucidate the structure of GPRC5D complexed with the Fab fragment of talquetamab, using cryo-electron A single talquetamab Fab interacts with the GPRC5D dimer with its orientation toward the dimer interface All six complementarity-determining regions of talquetamab engage with extracellular loops and TM3/5/

strategies in an international cohort of 139 patients (n = 130 ide-cel, n = 9 cilta-cel), receiving talquetamab Overall response and complete response upon salvage therapies were 79% and 39% for talquetamab, 64% and