< GPCR News < GPCRs in Oncology and Immunology Structural Basis for the Recognition of GPRC5D by Talquetamab Talquetamab, a Food and Drug Administration-approved T-cell-directing bispecific antibody developed for Here, we elucidate the structure of GPRC5D complexed with the Fab fragment of talquetamab, using cryo-electron A single talquetamab Fab interacts with the GPRC5D dimer with its orientation toward the dimer interface All six complementarity-determining regions of talquetamab engage with extracellular loops and TM3/5/