September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways events (P = 0.019) and liver metastasis (P = 0.011). At a median follow-up interval of 67.1 months, a significant trend towards reduced distant metastasis-free Besides, high GPER expression was significantly linked to the worse survival in patients with lymph node metastasis Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways

organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote tumor proliferation and metastasis

However, GRK3’s functions and clinical utility in GAC progression and metastases are unknown. Methods We studied GRK3 expression in normal, primary, and metastatic GAC tissues.

2024 Abstract "The accumulation of ascites in patients with ovarian cancer increases their risk of transcoelomic metastasis. restriction of ascites accumulation as maintenance strategies for overcoming mechanotransduction-mediated metastasis shear stress , glycocalyx , high grade serous ovarian cancer , mechanotransduction , mucin 15 (MUC15) , transcoelomic metastasis Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News

In cancer, chemokines play paradoxical roles in both the directed emigration of metastatic, receptor-expressing Drouillard, Brian T Craig, Michael B Dwinell Tags Chemokine receptor; cell migration; immuno-oncology; metastasis

melanoma cells in the tumor microenvironment Published date December 23, 2022 Abstract Due to its high metastatic tumor microenvironment (= TME, inverse pH-gradient) is a well-known driver of tumor progression and metastasis