Recent advancements in transcriptomic profiling have provided new insights into the expression patterns semi-quantitative multiplex PCR method, which allowed for the detection of both abundant and rare GPCR transcripts

Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and their Here, we generated a transcriptome of the central nervous system (CNS) of G. molesta.

Based on our transcriptomic analysis, expression of GPER was correlated with clinicopathological variables Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways

In addition to transcriptomic analysis, mutational profiles revealed that somatic mutations in OR genes Based on this systematic analysis and review of the genomic and transcriptomic profiles of ORs in glioma

Using multiplexed single-cell transcriptomics, we analyze human neural precursor cells (hNPCs) from sporadic

perspectives of CXCR4 antagonists for disease therapy GPCRs in Cardiology, Endocrinology, and Taste Transcriptomic stress mechanotransduction at endothelial junctions GPCRs in Neuroscience Male-specific behavioral and transcriptomic

Non-biased transcriptomic analyses of dorsal-horn spinal cord (DH-SC) tissues harvested at the time of significant activation of MAPKs (extracellular signal-regulated kinase [ERK], p38) and redox-sensitive transcription

GPCRs in Oncology and Immunology Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics

Avila-Zozaya , our incredible contributor, for her fantastic article on Profiling Immune Cell and Platelet Transcriptomes

Single-cell transcriptome analysis of NEUROG3+ cells during pancreatic endocrine differentiation with Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney

inhibiting inflammation and promoting cell self-renewal in mice Methods & Updates in GPCR Research Transcriptome

Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat

Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression

positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma Unbiased multitissue transcriptomic

vasoregulatory and autonomic nervous system receptors Methods & Updates in GPCR Research Multi-tissue transcriptomic

Additionally, genomic approaches such as transcriptomics and proteomics have provided insights into the

molecules that inhibit midgut contractions GPCRs in Cardiology, Endocrinology, and Taste Single-cell transcriptomic

October 2022 Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent GPCRs) are now thought to use endocytosis to promote cellular cAMP signaling that drives downstream transcription

enhances cardiomyocyte death after myocardial infarction through β1 adrenergic receptor Comparative transcriptomic

but not cannabidiol, on the cannabinoid CB2 receptor GPCRs in Cardiology, Endocrinology, and Taste Transcriptomic

Transcriptomic analysis of human cytomegalovirus to survey the indirect effects on renal transplant recipients

Transcriptome profiling of male and female Ascaris lumbricoides reproductive tissues.

single OR gene however, ectopic ORs expression is unlikely to be modulated by this tight mechanism with transcriptomic

and more Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic

A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent transcription in signalling cascade that increases excitability and facilitates plasticity, partly through the regulation of transcription Upon activation via D1R, PKA can translocate to the nucleus to regulate transcription through the phosphorylation One candidate effector of PKA-dependent transcriptional regulation is the BET protein Brd4. However, it is unknown whether BET proteins, or Brd4 specifically, are involved in transcriptional activation

protease-activated receptor 4 (PAR4) unexpectedly acts as a potent oncogene, inducing β-catenin stability and transcriptional β-catenin suppresses the ubiquitination of β-catenin, thereby promoting PAR-induced β-catenin stability and transcriptional lysine, as well as serine/threonine residues, exhibits low levels of β-catenin and a markedly reduced transcriptional Taken together, we reveal that PAR-induced post-transcriptional regulation of β-catenin is centrally

A growing number of GPCRs have been shown to be localized in the nucleus and contribute toward transcriptional , such as the functional relevance of this localization, and whether H2R can contribute directly to transcriptional

Showing that this spatially biased signaling through arrestins can influence transcriptional responses regulate distinct cellular processes, including phospholipase C epsilon (PLCε)-dependent signaling and transcriptional Furthermore, GPCRs localized to the nuclear membrane have emerged as important regulators of gene transcription metabotropic glutamate receptor 5 (mGluR5), can lead to sustained calcium signaling and activation of transcription Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription