CCR12a1, CCR12a2, and CCR12b) in largemouth bass (Micropterus salmoides) The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells Methods & Updates in GPCR Research Generation

August 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate the regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent manner during epithelial tube formation

September 2022 "Epithelial tube formation requires Rho1-dependent actomyosin contractility to generate regulates distinct myosin pools and actin cytoskeleton in a ligand-dependent manner during epithelial tube formation

September 2022 Fly casting with ligand sliding and orientational selection supporting complex formation

December 2021 Crinetics Pharmaceuticals announced the formation of an independently operated new company endocrine-related tumors, together with 5AM Ventures and Frazier Healthcare Partners, today announced the formation

of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation αIIbβ3 are key signaling receptors in collagen-dependent platelet aggregation and in arterial thrombus formation Microscopic thrombus formation was assessed by eight parameters (with script descriptions enclosed). Blockage of PTK2 or interference of CIB1 no more than slightly affected thrombus formation at a low shear shear-dependent signaling axis of PTK2, integrin αIIbβ3, and CIB1 in collagen- and GPVI-dependent thrombus formation

The physiological mechanisms driving synapse formation are elusive. postsynaptic cAMP levels or of cAMP-dependent protein-kinase activity severely impairs excitatory synapse formation without affecting neuronal maturation, dendritic arborization, or inhibitory synapse formation. Given that postsynaptic latrophilin adhesion-GPCRs drive synapse formation and produce cAMP, we suggest restricted postsynaptic cAMP signals organize assembly of postsynaptic specializations during synapse formation

Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Further studies showed that ADGRA1 deficiency resulted in higher dendritic branching complexity and spine

August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular

different immune cell types, including B cells, CD4+ T cells, CD8+ T cells, natural killer (NK) cells, and dendritic

Interestingly, in monocytes and dendritic cells exposed to treatments mimicking inflammation, CCR1, CCR2

The mouse cytomegalovirus (MCMV) GPCR, M33, facilitates dendritic cell (DC)-dependent viremia, the extravasation

CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes.

In monocytes and dendritic cells exposed to treatments mimicking inflammation, CCR1, CCR2, and CCR5 switch

described for CCR7 where it specifically affects the recognition of CCL21 but not CCL19, interfering with dendritic

Recent studies have revealed that PGs play pivotal roles in embryo development, ciliogenesis, and organ formation development, PGE2 signaling regulates embryogenesis, hepatocyte differentiation, hematopoiesis, and kidney formation functions and mechanisms of prostaglandin signaling in ciliogenesis, embryo development, and organ formation

February 2022 "Ermium Therapeutics Announces the Formation of a Scientific Advisory Board comprising

higher organism, as it allows for prioritizing of vital information, preparation of responses, and formation both NPS receptor (NPSR1) and NPS precursor knockout mice in fear extinction or novel object memory formation

GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5 homo- and hetero-dimer formation First, we observed the formation of endogenous SST5 homo-dimers in GH3, A7, and M2 cells. in GH3 cells SST2 and SST5 can form both homo- and hetero-dimers and that FLNA plays a role in the formation

are expressed widely and involved in various functions including development, angiogenesis, synapse formation Knockdown of GPR125 as well as that of Dlg1 results in formation of aberrant cysts with multiple lumens

DVT formation is a time-dependent inflammatory process in which NETosis plays an important role.

Here, we ask the question whether agonists with very slow off-rates can cause the formation of particularly

studies reported that the biased properties of ligands and receptors are a consequence of GPCR dimer formation Different models of dimer formation have been described for different receptors such as the ‘rolling Recent studies found that peptides derived from the transmembrane region of GPCRs can block the formation

Until now, the mechanisms and signaling pathways between platelets and neutrophils inducing NET formation that potently activates neutrophils and leads to massive neutrophil infiltration into the lung and NET formation

The enhanced signalling observed in GPCR priming is attributed to the formation of temporal non-cognate-GPCR Okashah, N., et al., Agonist-induced formation of unproductive receptor-G(12) complexes. 

of the specific arginine residue at position 125 of MRAP2, which affects protein conformation, dimer formation

The formation of β2-AR dimers requires cholesterol on the plasma membrane.

neuronal apoptosis, axonal demyelination, Wallerian degeneration, axonal remodeling, and glial scar formation