< GPCR News < GPCRs in Oncology and Immunology The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells Published date October 29, 2024 Abstract "The intestinal activated by the gut bacterial metabolite pyruvate, is specifically expressed on type 1 conventional dendritic toward pyruvate on the luminal side, forming transepithelial dendrites (TED). efficient uptake of gut luminal antigens, such as dietary compounds and bacterial particles through TED formation

< GPCR News < GPCRs in Oncology and Immunology CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes Published date March 21, 2023 Abstract "Dendritic cells (DCs) and monocytes

neutrophils (CD11b + Gr1+), monocytes (CD11b + Gr1-Ly6C+ and CD11b + Gr1-Ly6C-), macrophages (F4/80+), and dendritic Gpr141 -/- mice showed increased CD11b + Gr1+ neutrophils, CD11b + Gr1- monocytes, CD11c+ dendritic cells Moreover, CD11c+ dendritic cells (DCs) purified from Gpr141 -/- mice increased cytokine production of functions as a negative regulator of immune responses by controlling the functions of monocytes and dendritic Akira Nakamura, Ryo Goitsuka, Tomonori Kaifu Tags G protein–coupled receptor 141 , autoimmune disease , dendritic

combinatorial and complete GRK knockouts in four primary immune cell types (neutrophils, T cells, B cells and dendritic Lastly, we provide evidence that complete GRK deficiency impairs dendritic cell homeostasis, which unexpectedly results from defective dendritic cell differentiation and maturation in vitro and in vivo . M Glaser, Teresa K Tarrant, Tim Lämmermann Tags B cells; G-protein coupled receptors; GRK; T cells; dendritic

September 10, 2024 Abstract "Skin psoriasis is defined as receiving external stimulation to activate skin dendritic In this research, our team allocated GPR97 depletion (GPR97-/-), GPR97 conditional depletion on dendritic

We have used the method to profile GPCR transcripts in white blood cells (WBCs)-B, CD4, CD8, NK, and dendritic

Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and

< GPCR News < GPCRs in Oncology and Immunology Gi/o GPCRs drive the formation of actin-rich tunneling OXER1 by its natural agonist, the eicosanoid 5-oxo-eicosatetraenoic acid (5-oxo-ETE), leads to the formation Consistent with the established role of Rho small GTPases in the formation of actin-rich projecting structures PI3K-regulated guanine nucleotide exchange factor (GEF) FARP1 as a GPCR effector essential for TNT formation

The formation of GLI-A/GLI-R requires cilia. the cilia-dependent derepression phenotypes arose in three modes: lack of GLI-R only, excess GLI-A formation only, or dual regulation of either lack of GLI-R or excess GLI-A formation.

< Back to Full Agenda Session VI AGPCRs shaping the nervous system ADGRCs in glutamatergic synapse formation ADGRL3) modulation of dopaminergic neurotransmission Nicole Perry-Hauser ADGRCs in glutamatergic synapse formation synapses and interact with synaptic scaffold proteins and glutamate receptors and are responsible for the formation I will also present ongoing work on the signaling mechanisms of how ADGRCs regulate synapse formation receptors’ adhesive properties influence signaling events, and in turn whether signaling impacts synapse formation

receptors’ adhesive properties influence signaling events, and in turn, whether signaling impacts synapse formation

and proliferation, suppresses cell apoptosis, heightens resistance to cisplatin, and promotes tumor formation , and proliferation, promotes cell apoptosis, increases sensitivity to cisplatin, and affects tumor formation

whereas ubiquitination of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation

Requirements: Resolution 300 ppi max, JPEG/TIFF/EPS/PNG/PDF formats, 5MB max Open to all adhesion GPCR

specifically, we investigate the druggability potential of new signaling partners we identified that drive the formation

Authors Nick D Bergkamp , Jeffrey R van Senten , Hendrik J Brink , Maarten P Bebelman , Jelle van den

He showed the formation of melatonin receptor heteromers in vitro and in vivo and their importance in

His lab is also interested in identifying novel signal transduction mechanisms of GPCRs, such as the formation

Here, we demonstrate that negative charges in the CMKLR1 N-terminus are involved in the formation of

Podcast Format, Team Culture, and Science Yamina and Arthur concluded their discussion and decided to They talked about the format and length of their podcast, their professional interests, and their recent They also explored the idea of starting a similar talk show format to 'Between Two Ferns', the importance

Podcast Format, Team Culture, and Science Yamina and Arthur concluded their discussion and decided to They talked about the format and length of their podcast, their professional interests, and their recent They also explored the idea of starting a similar talk show format to 'Between Two Ferns', the importance

His lab is also interested in identifying novel signal transduction mechanisms of GPCRs, such as the formation

The NMDA receptor is a subtype of glutamate neurotransmitter receptor that regulates the formation and

Notably, GPR132 activation by 8GL promoted differentiation and reduced colony formation in human AML

PAG is a potential diagnostic marker for CVD as it causes serious fatal conditions such as thrombus formation

A combination of dasatinib and trametinib potently and synergistically inhibited colony formation by

These results provide new insights into the role of Wnt and Gs-signaling in fibrosis and bone formation

CheY protein) was found to interact with -4319.76, -5271.39, and -4725.57 of the docked score and the formation