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GPCR News < GPCRs in Oncology and Immunology RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment Published date November 20, 2023 Abstract " Background: Regulator of G protein signaling However, its role in normal and tumor vascular remodeling is controversial. Furthermore, tumor-derived RGS5 could be transferred into VSMCs. Conclusions: These findings suggest that tumor microenvironment shifts the function of RGS5 from anti-inflammation

< GPCR News < GPCRs in Oncology and Immunology Metabolic crosstalk: Extracellular ATP and the tumor microenvironment signals inside the body, which is necessary for controlling the life activities of all cells, including tumor Its significance extends from intracellular signaling pathways to tumor regression. In the tumor microenvironment (TME), purinergic receptors such as ATP-gated ion channels P2X1-5 and G microenvironment (TME) Source Contribute to the GPCR News Coming soon Become a Contributor Classified

News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment Published date December 23, 2022 Abstract Due to its high metastatic potential, malignant In melanoma as well as in other cancers, acidification of the tumor microenvironment (= TME, inverse pH-gradient) is a well-known driver of tumor progression and metastasis. Results indicate that GPR4 is involved in the migration of melanoma cells, especially in the tumor periphery

of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma Published date September 16, 2023 Abstract "Background: In this study, Jianying Gu Tags G protein-coupled receptors , Immunotherapy , Melanoma , Multi-omics , Pan-cancer , Tumor microenvironment , scRNA-seq Source Contribute to the GPCR News Coming soon Become a Contributor Classified

GPCRs in Oncology and Immunology G protein-coupled receptor-mediated signaling of immunomodulation in tumor Published date July 31, 2024 Abstract "G protein-coupled receptors (GPCRs) are essential contributors to tumor Here, we discuss the current understanding of the roles of GPCRs and their signaling pathways in tumor Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells , tumor microenvironment .

HDAC) activities, protein modifications, signaling pathways, and gene expression in cells within the tumor microenvironment, particularly in tumor and immune cells. The critical role of SCFAs in maintaining normal homeostasis and influencing tumor progression highlights

P2Y12R activation can promote platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis , and affect the tumor immune microenvironment (TIME) and tumor drug resistance, which is conducive to We explored the role of P2Y12R inhibitors in different tumors and the latest advances by summarizing the basic and clinical studies on the effects of P2Y12R inhibitors on tumors." , Tumor microenvironment Source Contribute to the GPCR News Coming soon Become a Contributor Classified

GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment A defining hallmark of GBM is a highly acidic tumor microenvironment, which is thought to activate pro-tumorigenic Low extracellular pH confers radioresistant tumors to glial cells. However, the role of tumor microenvironment acidification in GPR68 activation has not been assessed in Results: We used a pHLourin2 probe to demonstrate how glioblastoma cells acidify their microenvironment

paradoxical roles in both the directed emigration of metastatic, receptor-expressing cancer cells out of the tumor as well as immigration of tumor infiltrating immune cells that culminate in a tumor unique immune microenvironment chemokine gradients within the unique spatial topography and temporal influences within heterogenous tumors receptor activation influence the signaling machinery that drive cellular movement into and out of the tumor microenvironment.

approach to treating patients suffering from lung cancer is to target surface receptors overexpressed on tumor cells, such as GPCR-family kinin receptors, and proteases that control tumor progression, such as kallikrein-related cancers, such as prostate and ovarian cancer, facilitating the invasive and metastatic capacity of tumor of KLKs in this neoplasm are modulated by the secretome of the different cell types present in the tumor microenvironment, the cancer subtype and the tumor stage, among others.

GPCR News < GPCRs in Oncology and Immunology GPCR signaling contributes to immune characteristics of microenvironment Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated virus-cancer interaction on microenvironment , Li Wang , Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1 , Epstein-Barr virus , Lymphoma , Microenvironment

polyadenylation as a targetable driver of pancreatic cancer, and 2) dysregulation of the pancreatic tumor microenvironment by commonly prescribed anti-anxiety drugs." Ricky's group at UPenn to explore the GPCR side of the lab, which led to the discovery of potential tumor microenvironment. microenvironment.

GPR81 KD increased spheroid necrosis, reduced invasion and in vivo tumor growth, and altered expression F Pedersen Tags EPHA7 , Extracellular matrix , HCAR1 , Metabolite GPCR , Notch , PCDH7 , Spheroid , Tumor microenvironment Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR

Invasive procedures alone are not effective at completely removing such tumors. Within this dataset, we observed the association in the tumor microenvironment between the gene expression

< GPCRs in Oncology and Immunology Aberrant hormone receptors regulate a wide spectrum of endocrine tumors of diverse GPCRs and their ligands play an important role in the over-function of various endocrine tumours ; AVPR2, D2DR, and SSTR5 in pituitary corticotroph tumours; GLP1R, GIPR, and somatostatin receptors in medullary thyroid carcinoma; and SSTRs, GLP1R, and GIPR in other neuroendocrine tumours. to cortisol-secreting adrenal lesions, but also occurs in tumours of several other organs."

< GPCR News < GPCRs in Oncology and Immunology Noval insights and therapeutic strategies for tumor-induced antidiuretic hormones in Drosophila models has provided valuable insights into the mechanisms underlying tumor-induced insights could contribute to the advancement of diagnostic and therapeutic strategies for treating tumor-related

GPCRs in Oncology and Immunology Exploiting frequent and specific expression of PRL3 in pediatric solid tumors Published date September 21, 2023 Abstract "Phosphatase of regenerating liver 3 (PRL3) is a specific tumor However, its physiological expression in pediatric embryonal and mesenchymal tumors and its association Among 64 pediatric tumors, PRL3 was most frequently expressed in neuroblastoma (100%), rhabdomyosarcoma PRL3 was expressed in 75% of relapsed tumors and associated with shorter median event-free survival.

typical GPCR with a high affinity for adenosine, is widely expressed on immune cells, inhibiting anti-tumor Here, we identify that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) patients, closely related to their prognosis and positively correlated with tumor-associated macrophages We hypothesize that blocking A2aR on LUAD cells will inhibit the role of TAMs and control tumor growth Functionally, blocking A2aR significantly suppresses TAMs infiltration and attenuates tumor burden in

and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors characteristics of growth hormone (GH)-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors the GH change rate in the octreotide loading test, and WWC3, SERINC1, and ZFAND3 correlated with the tumor

Increasing evidence reveals the heightened expression of olfactory receptors in tumorous tissues and Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing a close relationship with tumor initiation and progression. The potential for precise tumor diagnosis and targeted therapy through therapeutic targeting of olfactory cell proliferation , Tumor development , Tumor metastasis .

receptors are clinically validated GPCR biomarkers for diagnosis and treatment of various neuroendocrine tumors performed immunohistochemistry of paired tissue microarrays containing 1125 cores, representing 43 tumor (ovarian and hepatocellular adenocarcinomas) as a function of their tumor stage. The expression prevalence of both receptors tends to decline with tumor progression. both SST2 and SST3 reemerged in metastases suggesting conserved receptors genetic potential during tumor

Trabecular Identity Abhishek Kumar Singh Investigating The Role of ADGRB3 Loss of Expression in Brain Tumor Glioblastoma (GBM) is the most prevalent central nervous system tumor in LFS, with TP53 mutations detected These observations lead me to hypothesize that ADGRB3 functions as a tumor suppressor in the brain, and expressed in renal AICs and ECs, and therefore are activated by distinct mechanisms unique to the cellular microenvironment Standard of care for MB includes tumor resection, chemotherapy, and cranio-spinal radiation.

As a member of the GPCR family, G protein-coupled receptor 37 (GPR37) exhibits unknown functions in tumors The study explored the influence of GPR37 on tumor cell proliferation. Furthermore, we examined the effects of GPR37 on tumor cell apoptosis and invasion. migration, and proliferation, suppresses cell apoptosis, heightens resistance to cisplatin, and promotes tumor migration, and proliferation, promotes cell apoptosis, increases sensitivity to cisplatin, and affects tumor

SCD1 axis Published date September 21, 2024 Abstract "Colorectal cancer (CRC) is a prevalent malignant tumor Depletion of GPR37 significantly reduced CRC tumor cell growth both in vitro and in vivo. Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1

Consistent with GAL2 receptor-mediated tumor inhibition, for PDAC, survival is much higher for patients AT2R is interacting with four tumor suppressor proteins, Src homology phosphatase 1, Src homology phosphatase Pathways linked to these tumor suppressor proteins may enhance immune surveillance, prevent carcinogenesis

Increased VIPR2 also exacerbated intraperitoneal proliferation of breast cancer MDA-MB-231 cells in a tumor Moreover, an inhibitor of mitogen-activated protein kinase kinase, U0126, attenuated tumor proliferation Together, these findings suggest that VIPR2 controls breast tumor growth by regulating the cAMP/PKA/ERK

Specifically, the review highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity, cancer cell expansion, and blood vessel development.

date October 13, 2023 Abstract "Background: Gliomas are the most frequently diagnosed primary brain tumors relationship between GPR37 gene expression and the clinicopathological factors, patient prognosis, tumor-infiltrating value, clinical relevance, and molecular function of GPR37 in glioma using TCGA, STRING, cBioPortal, Tumor