Octopamine and tyramine signalling in Aedes aegypti: Molecular characterization and insight into potential Webinars SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023). 2nd ERNEST Training

Signaling Function and is Essential for Thrombosis GPCRs in Oncology and Immunology Enterococcus-derived tyramine

We also show that the N-terminal region of anosmin 1, capable of binding to the PK2-binding domain of

October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of Searching for antagonist activity, we performed systematic N-terminal truncations of human GLP-2(1-33

Glycosylation and sulfation – N-terminal PTMs on chemokine receptors The interaction of chemokine receptors Within the CRS1 ineraction mode, the N-terminal region of chemokine receptors is indispensable for chemokine N-terminal PTMs include sulfation and glycosylation which contribute to the overall negative charge of (PAPS) donor to the hydroxyl group of a tyrosine residue of the protein chain (Seibert C and Sakmar TP. 2008) by tyrosine sulfotransferase 1 or 2 (TPST1/2).

recombinant protein constructs GST-CB1414-472 and GST-CB1414-442 containing much of the human CB1 receptor C-terminal To this end we used three different antibodies, all raised against a peptide comprising the C-terminal

apicobasal polarity "The adhesion family of G protein-coupled receptors (GPCRs) is defined by an N-terminal The products, i.e., the N-terminal and C-terminal fragments, seem to remain associated after self-proteolysis The recruitment likely requires the C-terminal PDZ-domain-binding motif of GPR125 and its interaction

flexible N-terminus, N-loop, three anti-parallel β-strands connected by 30s- and 40s-loops, and a C-terminal The N-terminal domains of CKRs has multiple sites for post-translational modifications, including tyrosine which are bound to a G-protein - two of the structures involve complex formation with endogenous N-terminal In ACKR3, the presence of a tyrosine at position 6.40 plays a role in its constitutive activity (Yen,

response, signaling downstream of an agonist-activated G protein-coupled receptor (GPCR) has to be rapidly terminated Among the family of GPCR kinases (GRKs) that regulate receptor phosphorylation and signaling termination

First, bosentan fluctuating randomly in solution is captured using a tip region of the flexible N-terminal Bosentan then slides occasionally from the tip to the root of the N-terminal tail (ligand–sliding). The bosentan-captured conformations by the tip-region and root-region of the N-terminal tail correspond

mGluR family and their activation leads to the inhibition of glutamate release from presynaptic nerve terminals and is also poised upstream of a myriad of signaling pathways in postsynaptic nerve terminals and neuroglia

Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal coupled receptor (GPCR), the PTH type 1 receptor (PTHR), is largely derived from studies done with its N-terminal

In presynaptic terminals, membrane-delimited Gi/o-mediated presynaptic inhibition is ubiquitous and acts At CA1-subicular presynaptic terminals 5-HT1B and GABAB receptors colocalize. Colocalization of different actions of GPCRs provide synaptic integration within presynaptic terminals Train-dependent presynaptic Ca2+ accumulation forces frequency-dependent recovery of neurotransmission Thus, stimulus trains in 5-HT1B receptor agonist unveil dynamic synaptic modulation and a sophisticated

We show that epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh

Cholesterol bound to the amino-terminal permease-like region of LYCHOS, and mutating this site impaired

Adhesion GPCRs GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent Meetings, and Webinars 2nd GPCR-Targeted Drug Discovery Summit | February 21-23, Boston. 2nd ERNEST Training

The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.

we assess β-arrestin conformational changes that are induced specifically by proximal and distal C-terminal

Here, we provide evidence that distal carboxyl-terminal tail (C-tail), but not proximal, phosphorylation

Here, we focused on disclosing the integrin-dependent roles of focal adhesion kinase (protein tyrosine

receptor 2 (PAR2) is a G-protein-coupled receptor (GPCR) activated by proteolytic cleavage of its N-terminal

Although it has been established that the palmitoylation of the C-terminal Go protein is essential for

Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal

a combination of insulin and the GPCR agonist neurotensin induced rapid activation of Src family of tyrosine

interactions with cell surface membrane proteins such as G-protein coupled receptors (GPCRs) and receptor tyrosine

Effective methods to treat preeclampsia are lacking, and termination of pregnancy remains the only curative

protein-coupled receptor (GPCR), which is activated by an endogenous peptide GPR15L(25-81) and a C-terminal

generating highly refined model structures of C5aR2, respectively in free (inactive), complexed to C-terminal